Gut Reactions #10 – New drug for Crohn’s disease receives UK licence

January 16, 2017 0

Ustekinumab is a drug designed to mimic normal human molecules, and for this reason is called a ‘biological’ drug. Results of a large well-conducted trial found that it is significantly better than placebo at inducing and maintaining remission in patients with moderate to severely active Crohn’s disease.

Interestingly, about 34% of patients who had failed earlier treatment with other biological agents (e.g. infliximab or adalimumab) improved within 6 weeks of a single injection of ustekinumab. In those patients who had not previously been treated with a biological agent, about 55% of them improved by week 6. Further doses were given to the patients that responded well to this treatment and about 53% of them remained in clinical remission for the duration of the study (44 weeks). Importantly, it was well-tolerated in all patients with no greater ‘adverse events rates’ than placebo.

The drug is not yet available in the NHS but is being appraised by NICE in 2017. For more information about this new treatment option, please do not hesitate to contact Dr Harris.


Leave a Reply

Your email address will not be published. Required fields are marked *



At West Kent Gastroenterology, we work hard to provide our patients with top-class care. You will enjoy friendly, fast and modern treatment by a highly experienced gastroenterologist. We carefully review patient satisfaction and feedback, and at West Kent Gastroenterology we are continuously making improvements to our services, ensuring the highest level of care possible.

Clinic Locations

Nuffield Hospital
Kingswood Road, Tunbridge Wells, TN2 4UL

Spire Hospital
Fordcombe Road, Tunbridge Wells, Kent, TN3 0RD

Sevenoaks Medical Centre
London Road, Sevenoaks, Kent, TN13 2JD

Twitter

@dradamharris - 3 months

Feels great to be back albeit behind a mask! WKG is offering remote and old fashioned face to face clinic and endoscopy appointments again.

@dradamharris - 6 months

Very pleased to be working as consultant physician at looking after patients from to c…

© 2020 West Kent Gastroenterology Ltd.

Designed and Developed By