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Broad and learned
clinical background

Gut Reaction #18: The 5:2 Diet

Over the last 20 years many patients have asked for my advice on losing weight (often following a discussion about hiatus hernia, reflux or fatty liver….). It appears that all diets work (albeit some quicker than others) when people ...

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Gut Reaction #17: Irritable Bowel Syndrome

IBS is a chronic disorder consisting of abdominal pain or discomfort associated with defaecation and/or accompanied by a change in stool form and frequency (constipation or diarrhoea or both). Usually, the abdominal pain or discomfort is either relieved by defaecation ...

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Gut Reaction #16: Microbiota and the Gut

There are billions of bacteria in the human gut and they are referred to as the gut microbiome. Its role in health and disease is the subject of extensive research. Imbalance of the normal gut microbiota, or dysbiosis, is thought to be ...

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Gut Reaction #15: The LINX procedure for Gastro-Oesophageal Reflux Disease (GORD)

Gut Reaction #15: The LINX procedure for Gastro-Oesophageal Reflux Disease (GORD) Gastro-Oesophageal Reflux Disease, or GORD, is a chronic relapsing condition whereby stomach acid refluxes back into the lower part of the gullet, or oesophagus, due to a weak muscle ...

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Gut Reaction #14: Risankizumab – Targeting interleukin 23 for Crohn’s disease

Gut Reaction #14: Risankizumab - Targeting interleukin 23 for Crohn’s disease The Lancet recently published results from a study which assessed the efficacy and safety of risankizumab, a monoclonal antibody that targets interleukin-23 only (ustekinumab targets interleukin-21 and 23), in ...

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Gut Reaction #13: Functional disorders

Functional disorders concern both mind and body – a patient’s emotional and psychological state can affect, or create, physical symptoms. These symptoms are absolutely genuine but are not due to an underlying physical abnormality or disease. Therefore patients may display ...

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Gut Reaction #12 – Filgotinib; a future treatment for patients with Crohn’s disease?

Filgotinib is a Janus kinase 1 (JAK1) inhibitor, that was reported in The Lancet to show positive results in patients with Crohn’s disease. Filgotinib is a “small molecule drug” that is taken by mouth & unlike the existing treatments for ...

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Gut Reactions #11 – Symprove probiotic for irritable bowel syndrome

Irritable Bowel Syndrome affects up to 20% of the UK population with women at least twice as likely to be affected as men. Common symptoms include bloating, constipation, diarrhoea and abdominal discomfort. While there is no clearly defined cause of ...

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Gut Reactions #10 – New drug for Crohn’s disease receives UK licence

Ustekinumab is a drug designed to mimic normal human molecules, and for this reason is called a ‘biological’ drug. Results of a large well-conducted trial found that it is significantly better than placebo at inducing and maintaining remission in patients ...

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Gut Reactions #9 – New treatment for active ulcerative colitis (UC)

Tofacitinib is a new JAK inhibitor taken by mouth 10mg twice daily. Recent trials (OCTAVE) have shown significant benefit in patients with moderately active UC. The patients had previous failure or intolerance to conventional treatments. Patients receiving tofacitinib were significantly ...

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